AIM 1: DETERMINATION IF DIRECT INHIBITION OF INSULIN RELEASE WITH DIAOXIDE DE

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。多囊卵巢综合征(PCOS)是一种知之甚少的疾病，影响大约6%-10%的育龄妇女。多囊卵巢综合征的特点是慢性无排卵和高雄激素血症，是美国女性不孕的主要原因。大多数患有多囊卵巢综合征的妇女还具有胰岛素抵抗的特点，这在多囊卵巢综合征的发病机制中发挥了关键作用，也使受影响的妇女患2型糖尿病的风险增加。这项研究的长期目标是阐明胰岛素抵抗与多囊卵巢综合征的关系。约翰·内斯特勒博士被认为是这一研究领域的专家。这笔赠款是他之前在PCOS女性方面尖端工作的一个非常明确的延续。年龄在17岁到40岁之间的女性将被招募。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The polycystic ovary syndrome (PCOS) is a poorly understood disorder that affects approximately 6-10% of women of reproductive age. PCOS is characterized by chronic anovulation and hyperandrogenism, and is a leading cause of female infertility in the United States. Most women with PCOS are also characterized by insulin resistance, which plays a key role in the pathogenesis of PCOS and also places affected women at increased risk for developing type 2 diabetes. The long-term goal of this study is to elucidate the relationship between insulin resistance and PCOS. Dr. John Nestler is considered an expert in this area of research. This grant is a very clear continuation of his previous cutting edge work with PCOS women. Women will be recruited between the ages of 17 to 40.