AIM 2:DETERMINATION IF INDIRECTLY REDUCING CIRCULATING INSULIN BY IMPROVING I

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 多囊卵巢综合征（PCOS）是一种知之甚少的疾病，影响大约6-10%的育龄妇女。 PCOS的特征是慢性无排卵和高雄激素血症，是美国女性不孕的主要原因。 大多数患有PCOS的女性还具有胰岛素抵抗的特征，胰岛素抵抗在PCOS的发病机制中起着关键作用，并且还使受影响的女性患2型糖尿病的风险增加。 本研究的长期目标是阐明胰岛素抵抗与PCOS之间的关系。 博士John Nestler被认为是这一研究领域的专家。 这笔赠款是他以前与PCOS妇女的前沿工作的一个非常明确的延续。 将招募17至40岁的妇女。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The polycystic ovary syndrome (PCOS) is a poorly understood disorder that affects approximately 6-10% of women of reproductive age. PCOS is characterized by chronic anovulation and hyperandrogenism, and is a leading cause of female infertility in the United States. Most women with PCOS are also characterized by insulin resistance, which plays a key role in the pathogenesis of PCOS and also places affected women at increased risk for developing type 2 diabetes. The long-term goal of this study is to elucidate the relationship between insulin resistance and PCOS. Dr. John Nestler is considered an expert in this area of research. This grant is a very clear continuation of his previous cutting edge work with PCOS women. Women will be recruited between the ages of 17 to 40.