IN VIVO STUDIES OF INSULIN SECRETION AND RESISTANCE IN FAMILIES

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。这项研究的重点，自成立以来，一直在调节胰岛素刺激的葡萄糖处置和葡萄糖刺激的胰岛素分泌的因素。特别是，重点已经放在证明脂肪组织在这些过程中发挥了核心作用。根据我们的研究结果以及其他人的相关发现，本研究的目的是检验以下假设：1）胰岛素抵抗个体对血糖浓度特定增量的胰岛素分泌增强;和2）在胰岛素抵抗个体中，游离脂肪酸（FFA）浓度升高对葡萄糖刺激的胰岛素分泌的抑制作用被夸大。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The focus of this research, since its inception, has been on factors regulating insulin-stimulated glucose disposal and glucose-stimulated insulin secretion. In particular, emphasis has been placed on demonstrating that adipose tissue plays a central role in these processes. Based upon the results of our studies, as well as relevant findings of others, the goal of this study is to test the following hypotheses: 1) insulin secretion in response to a given increment in plasma glucose concentration is enhanced in insulin-resistant individuals; and 2) the inhibition of glucose-stimulated insulin secretion by elevated free fatty acid (FFA) concentrations is exaggerated in insulin-resistant individuals.