LIPEMIA: CARBOHYDRATE AND GLYCERIDE METABOLISM
脂血症:碳水化合物和甘油酯代谢
基本信息
- 批准号:7605156
- 负责人:
- 金额:$ 7.37万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2007
- 资助国家:美国
- 起止时间:2007-02-15 至 2007-11-30
- 项目状态:已结题
- 来源:
- 关键词:AmericanCarbohydratesComputer Retrieval of Information on Scientific Projects DatabaseConsensusCoronary ArteriosclerosisDefectDietEatingFatty acid glycerol estersFundingGlucoseGlucose Plasma ConcentrationGlyceridesGrantHigh Density Lipoprotein CholesterolHypertensionIndividualIngestionInstitutionInsulinLeadLow-Density LipoproteinsMetabolicMetabolismNon-Insulin-Dependent Diabetes MellitusPatientsPharmacotherapyPlasmaResearchResearch PersonnelResourcesRiskSourceTriglyceridesUnited States National Institutes of Healthdensityfallshypertension treatmentsymposium
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
The NIH has recently distributed the results of a consensus conference, which urges that "all Americans" consume low fat-high carbohydrate diets. Previous results from our research group have demonstrated that the ingestion of low fat-high carbohydrate diets by normal individuals or patients with non-insulin-dependent diabetes can lead to an increase in plasma concentrations of glucose, insulin, triglyceride (TG), as well as a fall in both plasma high density and low density lipoprotein (LDL) concentrations. Since the risk of developing coronary artery disease (CAD) has been shown to be associated with all of these metabolic changes, questions can be raised as to the appropriateness of the advice that "all Americans" eat low fat/high carbohydrate diets. Recent observations have shown that patients with untreated hypertension have higher than normal plasma glucose, insulin and TG concentrations. Institution of several forms of anti-hypersensitive drug therapies have been shown to accentuate these metabolic defects as well as lower plasma HDL-cholesterol concentration. Indeed, the presence of these metabolic abnormalities may explain why treatment of hypertension has not reduced the risk of coronary artery disease. Given the presence of the metabolic defects outlined above, and the fact that these same changes are aggravated by low fat/high carbohydrate diets, it is necessary to raise the possibility that the recommended dietary change may increase, not decrease, the risk of CAD in patients with hypertension.
这个子项目是众多研究子项目之一
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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GERALD M. REAVEN其他文献
GERALD M. REAVEN的其他文献
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{{ truncateString('GERALD M. REAVEN', 18)}}的其他基金
Sleep apnea, Type 2 diabetes, and CVD: a cluster related to insulin resistance
睡眠呼吸暂停、2 型糖尿病和 CVD:与胰岛素抵抗相关的一组疾病
- 批准号:
8321395 - 财政年份:2011
- 资助金额:
$ 7.37万 - 项目类别:
Sleep apnea, Type 2 diabetes, and CVD: a cluster related to insulin resistance
睡眠呼吸暂停、2 型糖尿病和 CVD:与胰岛素抵抗相关的一组疾病
- 批准号:
8499411 - 财政年份:2011
- 资助金额:
$ 7.37万 - 项目类别:
Sleep apnea, Type 2 diabetes, and CVD: a cluster related to insulin resistance
睡眠呼吸暂停、2 型糖尿病和 CVD:与胰岛素抵抗相关的一组疾病
- 批准号:
8698805 - 财政年份:2011
- 资助金额:
$ 7.37万 - 项目类别:
Sleep apnea, Type 2 diabetes, and CVD: a cluster related to insulin resistance
睡眠呼吸暂停、2 型糖尿病和 CVD:与胰岛素抵抗相关的一组疾病
- 批准号:
8138080 - 财政年份:2011
- 资助金额:
$ 7.37万 - 项目类别:
Beneficial Effect of Salicylates: Insulin action, Secretion or Clearance?
水杨酸盐的有益作用:胰岛素作用、分泌或清除?
- 批准号:
8280429 - 财政年份:2010
- 资助金额:
$ 7.37万 - 项目类别:
Beneficial effect of salicylates: insulin action, secretion or clearance?
水杨酸盐的有益作用:胰岛素作用、分泌或清除?
- 批准号:
7863404 - 财政年份:2010
- 资助金额:
$ 7.37万 - 项目类别:
Beneficial Effect of Salicylates: Insulin action, Secretion or Clearance?
水杨酸盐的有益作用:胰岛素作用、分泌或清除?
- 批准号:
8113392 - 财政年份:2010
- 资助金额:
$ 7.37万 - 项目类别:
CLINICAL TRIAL: FENOFIBRATE AND ROSIGLITAZONE IN INSULIN RESISTANT DYSLIPIDEMIC
临床试验:非诺贝特和罗格列酮治疗胰岛素抵抗性血脂异常
- 批准号:
7717859 - 财政年份:2007
- 资助金额:
$ 7.37万 - 项目类别:
RELATIONSHIP BETWEEN INSULIN RESISTANCE & EARLY DEV OF ATHEROGENESIS
胰岛素抵抗之间的关系
- 批准号:
7717843 - 财政年份:2007
- 资助金额:
$ 7.37万 - 项目类别:
IN VIVO STUDIES OF INSULIN SECRETION AND RESISTANCE IN FAMILIES
家庭胰岛素分泌和抵抗的体内研究
- 批准号:
7717840 - 财政年份:2007
- 资助金额:
$ 7.37万 - 项目类别:
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