INSULIN RESISTANCE: IT'S ROLE IN WEIGHT LOSS AND CARDIOVASCULAR RISK

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项研究的中心焦点是胰岛素介导的葡萄糖处置抵抗和代偿性高胰岛素血症在胰岛素抵抗(IR)调节中的重要性及其在体重减轻和心血管风险中的作用。本研究的目的是确定肥胖者的胰岛素抵抗/高胰岛素血症与减肥能力的关系。此外，还将讨论高胰岛素血症对冠心病风险的影响。非糖尿病患者和糖尿病患者都将被研究。该方案包括一项研究的几个活跃分支，该研究旨在评估常量营养素成分对以下方面的影响：1)减肥能力；2)在超重或肥胖的IR患者中降低心血管风险。整个研究筛选的预期受试者总数：300-400名登记：第1组：肥胖非糖尿病：60名第2组：仅肥胖糖尿病饮食：36名第3组：肥胖糖尿病单一疗法：45名第4组：超重非糖尿病：20名第5组：肥胖东南亚女性：20名脂肪组织活检亚研究：30名

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The central focus of this study is on the importance of resistance to insulin-mediated glucose disposal and compensatory hyperinsulinemia in modulation of insulin resistance (IR) and its role in weight loss and cardiovascular risk. The purpose of this study is to determine the relationship between insulin resistance/hyperinsulinemia and ability to lose weight in obese individuals. In addition, the impact of hyperinsulinemia on risk for coronary heart disease will be addressed. Both non-diabetics and diabetics will be studied. This protocol includes several active arms of a study designed to evaluate the impact of macronutrient composition on: 1) ability to lose weight 2) reduction in cardiovascular risk, among overweight or obese individuals with IR. Total subjects expected for entire study Screening: 300-400 Enrollment: Arm 1: obese nondiabetic: 60 Arm 2: obese diabetic diet only: 36 Arm 3: obese diabetic monotherapy: 45 Arm 4: overweight nondiabetic: 20 Arm 5: obese Southeast Asian women: 20 Adipose tissue biopsy substudy: 30