GENERAL CLINICAL RESEARCH CENTER

摘要 GCRC是斯坦福大学医学院的主要临床研究机构。 药该提案共涉及99项协议，39名主要研究者和50名合作者。 来自12个部门的调查人员。我们的目标是提供最佳设施， 开展以患者为导向的研究，将基本的科学知识转化为更好的 了解和治疗人类疾病，并培训临床卫生专业人员 research.斯坦福大学医院目前的空间提供了一个优秀的住院 和门诊GCRC设施，早产儿研究计划利用分散床 在附近的露西尔·帕卡德儿童医院八大计划和 构成该建议核心的调查人员是： (1)滤泡性非典型增生的重组独特型疫苗免疫治疗 霍奇金淋巴瘤（RonaldLevy）。 (2)HIV阳性患者的临床试验（托马斯C. Merigan）。 (3)手术治疗婴儿坏死性小肠结肠炎的随机试验 （劳伦斯·莫斯） (4)抑郁症患者下丘脑-垂体-肾上腺轴的研究 Schatzberg）。 (5)ZD 1839（易瑞沙）与奥沙利铂、5-氟尿嘧啶、 和Leucovorin in Advanced Solid Cancer（Branimir I.Sikic）。 (6)幽门螺杆菌传播的临床实验（Julie Parsonnet）。 (7)肝肾综合征的病理生理学（Bryan D. Myers）。 (8)血友病的基因治疗（Mark Kay和Bertil Glader）

ABSTRACT The GCRC is the major clinical research facility for Stanford University School of Medicine. This proposal involves a total of 99 protocols, 39 principal investigators, and 50 co- investigators from 12 departments. Our goals are to provide an optimal facility for the conduct of patient oriented research, to translate basic scientific knowledge into a better understanding and treatment of human diseases, and to train health professionals in clinical research. Current space in Stanford University Hospital provides an outstanding inpatient and outpatient GCRC facility, and a premature infant research program utilizes scatter beds in the adjacent Lucile Packard Children's Hospital. The eight major programs and investigators which form the core of this proposal are: (1) Recombinant Idiotype Vaccines for the Immunotherapy of Follicular Non- Hodgkin's Lymphomas (RonaldLevy). (2) Clinical Trials in HIV Positive Patients (Thomas C. Merigan). (3) Surgery for Necrotizing Enterocolitis in Human Infants: a Randomized Trial (Lawrence Moss). (4) Studies of Hypothalamic-Pituitary-Adrenal Axis in Psychotic Depression (Alan Schatzberg). (5) A Phase I Study of ZD1839 (Iressa) in Combination with Oxaliplatin, 5-Huorouracil, and Leucovorin in Advanced Solid Malignancies (Branimir I.Sikic). (6) Clinical Experiment of Helicobacter PyloriTransmission (Julie Parsonnet). (7) Pathophysiology of Hepatorenal Syndrome (Bryan D. Myers). (8) Gene Therapy for Hemophilia (Mark Kay and Bertil Glader).