Extramural Research Facilities Construction Boswell Fis*

校外研究设施建设 Boswell Fis*

• 批准号: 6862441
• 负责人: PHILIP A. PIZZO
• 金额: $ 235.52万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-20 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6862441
• 关键词: Extramural; Research; Facilities; Construction; Boswell

DESCRIPTION (provided by applicant): Stanford School of Medicine has developed a 20-year plan for research and facility development that includes expansion of existing programs and new Institutes for Stem Cell/Cancer Biology, Brain Research, Cardiovascular Medicine, and Immunology, Transplantation and Infection. As part of the planning we evaluated existing animal facilities and populations and identified the projected animal facilities to support this expansion, i.e., making the highest and best use of existing facilities and improving the quality of existing animal facilities. We found that mouse and aquatic/amphibious populations were increasing rapidly, but space constraints were affecting research and would eventually diminish the quality of animal husbandry. Mice, fish and frogs are major beneficiaries of the identification of genes and mutations linked to human diseases, because they are easily and inexpensively manipulated, and many of their genomes are now being sequenced. Aquatic/amphibious species, are rapidly becoming the species of choice for many sophisticated studies of gene interactions, cell signaling, and protein processing in molecular and developmental biology, the neurosciences and pharmacology. This proposal addresses three areas needed to support this expansion of biomedical research at Stanford University School of Medicine: 1) alleviating a shortage of appropriate facilities to accommodate the specific needs of sticklebacks, zebrafish, and frogs for controlled water quality, temperature, and light; 2) consolidating these facilities into an area to facilitate collaboration and husbandry support; 3) expansion of the rodent holding areas by removing fish and frogs from mouse facilities to facilities designed for their special needs.

描述(由申请人提供)： 斯坦福大学医学院制定了一项为期20年的研究和设施开发计划，其中包括扩大现有的干细胞/癌症生物学、脑研究、心血管医学以及免疫学、移植和感染方面的项目和新的研究所。作为规划的一部分，我们评估了现有的动物设施和种群，并确定了支持此次扩建的预计动物设施，即最高和最好地利用现有设施，并提高现有动物设施的质量。我们发现，老鼠和水生/两栖动物的数量正在迅速增加，但空间限制正在影响研究，并最终将降低畜牧业的质量。老鼠、鱼和青蛙是识别与人类疾病有关的基因和突变的主要受益者，因为它们很容易被廉价地操纵，它们的许多基因组现在正在进行测序。水生/两栖物种正在迅速成为分子和发育生物学、神经科学和药理学中许多关于基因相互作用、细胞信号和蛋白质加工的复杂研究的首选物种。该建议涉及支持斯坦福大学医学院扩大生物医学研究所需的三个领域：1)缓解适当设施的短缺，以满足刺鱼、斑马鱼和青蛙对受控水质、温度和光照的特殊需求；2)将这些设施合并为一个区域，以促进合作和畜牧业支持；3)扩大啮齿动物收容区，将鱼和青蛙从老鼠设施转移到为它们的特殊需求设计的设施。