General Clinical Research Center

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The GCRC is the major clinical research facility for Stanford University School of Medicine. This proposal is for a five year renewal, for years 45-49 of this research grant. It involves a total of 138 protocols and 147 investigators from 19 university departments. Our goals are to provide an optimal facility for the conduct of patient oriented research, to translate basic scientific knowledge into a better understanding and treatment of human diseases, and to train health professionals in clinical research. Current space in Stanford University Hospital provides an outstanding inpatient and outpatient GCRC facility, and a premature infant research program utilizes scatter beds in the adjacent Lucile Packard Children's Hospital. The seven major programs and investigators which form the core of this proposal are: (1) A Phase l/ll Study of Intratumoral Injection of CpG7909, a TLR Agonist, Combined with Local Radiation in Recurrent Low Grade Lymphomas (Ronald Levy). (2) Human Immune Response to Natural Infections and Vaccines (Cornelia J. Dekker). (3) Therapeutic Manipulation of the NOS Pathway in Peripheral Arterial Disease (John P. Cooke). (4) New Therapeutic Approaches for Colorectal Cancers (Branimir I. Sikic). (5) The Hypothalamic-Pituitary-Adrenal Axis in Psychotic Depression (Alan Schatzberg). (6) Neuroimaging and Neurodevelopmental Outcome (David Stevenson). (7) The Aging Kidney after Contralateral Nephrectomy (Bryan D. Myers).