General Clinical Research Center

GCRC是斯坦福大学医学院的主要临床研究机构。这 建议将该研究补助金延长五年，即45-49年。共涉及138个 来自19个大学部门的147名研究人员。我们的目标是提供一个最佳的 设施进行以病人为导向的研究，将基本的科学知识转化为 更好地了解和治疗人类疾病，并在临床方面培训卫生专业人员 research.斯坦福大学医院目前的空间提供了一个优秀的住院病人， 门诊GCRC设施和早产儿研究计划利用分散床在 露西尔·帕卡德儿童医院附近七个主要项目和调查人员， 这一建议的核心是： (1)肿瘤内注射TLR激动剂CpG 7909与局部化疗联合的I/II期研究 复发性低度恶性淋巴瘤的放射治疗（罗纳德利维）。 (2)人类对自然感染和疫苗的免疫应答（科尔内利亚J. Dekker）。 (3)外周动脉疾病中NOS通路的治疗操作（John P. Cooke）。 (4)结肠直肠癌的新治疗方法（Branimir I。Sikic）。 (5)精神病性抑郁症的下丘脑-垂体-肾上腺轴（Alan Schatzberg）。 (6)神经影像学和神经发育结局（大卫史蒂文森）。 (7)单侧肾切除术后的衰老肾脏（Bryan D。迈尔斯）。

The GCRC is the major clinical research facility for Stanford University School of Medicine. This proposal is for a five year renewal, for years 45-49 of this research grant. It involves a total of 138 protocols and 147 investigators from 19 university departments. Our goals are to provide an optimal facility for the conduct of patient oriented research, to translate basic scientific knowledge into a better understanding and treatment of human diseases, and to train health professionals in clinical research. Current space in Stanford University Hospital provides an outstanding inpatient and outpatient GCRC facility, and a premature infant research program utilizes scatter beds in the adjacent Lucile Packard Children's Hospital. The seven major programs and investigators which form the core of this proposal are: (1) A Phase l/ll Study of Intratumoral Injection of CpG7909, a TLR Agonist, Combined with Local Radiation in Recurrent Low Grade Lymphomas (Ronald Levy). (2) Human Immune Response to Natural Infections and Vaccines (Cornelia J. Dekker). (3) Therapeutic Manipulation of the NOS Pathway in Peripheral Arterial Disease (John P. Cooke). (4) New Therapeutic Approaches for Colorectal Cancers (Branimir I. Sikic). (5) The Hypothalamic-Pituitary-Adrenal Axis in Psychotic Depression (Alan Schatzberg). (6) Neuroimaging and Neurodevelopmental Outcome (David Stevenson). (7) The Aging Kidney after Contralateral Nephrectomy (Bryan D. Myers).