CRF AND PERSONALITY DISORDERS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。简介：童年创伤是许多精神病理学的危险因素，包括人格障碍。虽然人类童年创伤影响大脑导致人格障碍的机制尚不清楚，但存在涉及下丘脑-垂体轴的动物模型。大鼠和猴子的动物模型发现，早期生活创伤导致脑促肾上腺皮质激素释放因子沿着表达上调，同时行为应激反应增加。已经收集的初步数据与儿童创伤史和成人CSF促肾上腺皮质激素释放因子水平之间的直接关系一致。该项目的具体目的是调查童年创伤史（通过童年创伤问卷测量）与成人人格障碍受试者应激激素变化之间的关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: Childhood trauma is a risk factor for many psychopathologies, including personality disorder. Although the mechanism in humans by which childhood trauma affects the brain to cause personality disorder is unknown, animal models exist which implicate the hypothalamic-pitutary axis. Animal models in rats and monkeys find evidence that early life trauma causes an upregulation in the expression of brain corticotrophin-releasing factor along with increased behavioral stress reactivity. Pilot data that has already been collected is consistent with a direct realtionship between history of childhood trauma and adult CSF corticotropin-releasing factor levels. The specific aim of the proposed project is to investigate the realtionship between history of childhood trauma as measured by the Childhood Truama Questionnaire and stress hormone alterations in adult, personality disordered subjects.