CORTISOL METABOLISM AND CENTRAL ADIPOSITY AFTER MENOPAUSE

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。有证据表明，腹部脂肪与冠状动脉疾病（一种常见的心脏病）和2型糖尿病（也称为“成人发病糖尿病”）的风险增加有关。绝经后，女性腹部脂肪增加。先前的研究表明，脂肪含量较高的女性会产生更多的应激激素——皮质醇。有证据表明，当腹部脂肪细胞从体内取出（组织活检样本）时，它们含有一种酶，可以将可的松（激素的非活性形式）转化为皮质醇（激素的活性形式）。我们研究的第一个目标是测量腹部脂肪细胞在体内脂肪组织时将可的松转化为皮质醇的能力。我们研究的第二个目标是比较肥胖和正常体重的绝经后妇女代谢皮质醇的情况。我们想知道你全身以及腹部脂肪将可的松转化为皮质醇的能力。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There is evidence that abdominal fat is associated with increased risk for coronary artery disease (a common type of heart disease) and Type 2 diabetes mellitus (also known as 'adult onset diabetes'). After menopause women tend to gain fat in the abdominal region. Previous studies show that women with larger amounts of fat make more of a stress hormone called cortisol. There is evidence that when abdominal fat cells are taken out of the body (tissue biopsy samples), they have an enzyme that can convert cortisone (the inactive form of the hormone) to cortisol (the active form of the hormone). The first goal of our study is to measure the ability of abdominal fat cells to convert cortisone to cortisol while the fat tissue is in your body. The second goal of our study is to compare how obese and normal weight postmenopausal women metabolize cortisol. We want to find out the ability of your whole body as well as your abdominal fat to convert cortisone to cortisol.