CORTISOL METABOLISM AND CENTRAL ADIPOSITY AFTER MENOPAUSE

绝经后皮质醇代谢和中心性肥胖

• 批准号: 7719450
• 负责人: WENDOLYN S GOZANSKY
• 金额: $ 0.31万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719450
• 关键词: Abdomen; Adipocytes; Biopsy Specimen; Computer Retrieval of Information on Scientific Projects Database; Coronary Arteriosclerosis; Cortisone; Enzymes; Fatty acid glycerol esters; Funding; Goals; Grant; Heart Diseases; Hormones; Hydrocortisone; Institution; Measures; Menopause; Metabolism; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Postmenopause; Research; Research Personnel; Resources; Risk; Source; Stress; Tissues; United States National Institutes of Health; Weight; Woman; abdominal fat

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There is evidence that abdominal fat is associated with increased risk for coronary artery disease (a common type of heart disease) and Type 2 diabetes mellitus (also known as 'adult onset diabetes'). After menopause women tend to gain fat in the abdominal region. Previous studies show that women with larger amounts of fat make more of a stress hormone called cortisol. There is evidence that when abdominal fat cells are taken out of the body (tissue biopsy samples), they have an enzyme that can convert cortisone (the inactive form of the hormone) to cortisol (the active form of the hormone). The first goal of our study is to measure the ability of abdominal fat cells to convert cortisone to cortisol while the fat tissue is in your body. The second goal of our study is to compare how obese and normal weight postmenopausal women metabolize cortisol. We want to find out the ability of your whole body as well as your abdominal fat to convert cortisone to cortisol.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 有证据表明，腹部脂肪与患冠状动脉疾病(一种常见的心脏病)和2型糖尿病(也称为成人糖尿病)的风险增加有关。绝经后，女性的腹部往往会增加脂肪。以前的研究表明，脂肪含量较高的女性会产生更多的压力荷尔蒙，称为皮质醇。有证据表明，当腹部脂肪细胞被从体内取出(组织活检样本)时，它们具有一种酶，可以将皮质醇(激素的非活性形式)转化为皮质醇(激素的活性形式)。我们研究的第一个目标是测量腹部脂肪细胞在脂肪组织在体内时将皮质醇转化为皮质醇的能力。我们研究的第二个目标是比较肥胖和正常体重的绝经后妇女如何代谢皮质醇。我们想要了解你全身和腹部脂肪将皮质醇转化为皮质醇的能力。