GENES OF HYPERTENSION IN AFRICAN AMERICANS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。我们假设，我们将能够确定基因有助于高血压在非洲裔美国人通过关注的生理途径，决定动脉压。我们建议广泛表型500高血压和500血压正常的非裔美国人进行遗传关联研究，使用SNP基因组扫描方法。表型的纳入是基于其与高血压病理生理学的相关性和先前的“遗传性”证据。SNP分析的候选基因将基于我们和其他人之前鉴定的QTL。该项目的最终目标是确定是否可以识别不同的血压相关表型簇，这将允许将高血压个体分层为不同的亚组，以便于分析高血压的遗传决定因素。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We hypothesize that we will be able to identify genes contributing to hypertension in African Americans by focusing on the physiological pathways that determine arterial pressure. We propose to extensively phenotype 500 hypertensive and 500 normotensive African American subjects to conduct a genetic association study, using a SNP genomic scan approach. Inclusion of phenotypes is based on their relevance to the pathophysiology of hypertension and prior evidence of "heritability". Candidate genes for SNP analysis will be based on QTLs previously identified by ourselves and others. A final goal of the project is to determine if distinct clusters of blood pressure-related phenotypes can be identified that will permit stratification of hypertensive individuals into distinct subgroups to facilitate the analysis of the genetic determinants of hypertension.