WHAS II

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。随着美国越来越关注如何减少与老龄化相关的残疾负担，我们一直在进行一项研究，以确定有残疾风险的老年妇女和残疾的原因。这项研究是在OPD-GCRC的空间和人员支持下进行的，并通过国家老龄问题研究所发起的题为“老龄妇女身体残疾的风险因素”的RO 1进行。这项研究被称为妇女健康与衰老研究II（WHAS II），是一项前瞻性观察性研究，研究对象为436名基线年龄在70-79岁之间的妇女，以确定早期功能衰退的特征，称为“临床前残疾”，临床前残疾的风险因素和根本原因，以及残疾和依赖性的进展，以及身体状况的早期下降是否功能是未来残疾的预测。2000年6月，通过R 01的竞争性更新，在5年内再进行3次检查，从而退还了研究费用。我们获得了无成本延期，以支持从2005年6月1日至2006年5月31日的研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. With concern increasing in the U.S. to understand how to decrease the burden of disability associated with aging, we have been conducting a study to define older women at risk of disability and the causes of disablement. This study is conducted with support of space and personnel from the OPD-GCRC and through an investigator-initiated RO1 from the National Institute on Aging entitled "Risk Factors for Physical Disability in Aging Women". The study, referred to as the Women's Health and Aging Study II (WHAS II), is a prospective, observational study of a cohort of 436 women 70-79 years of age at baseline, to determine the characteristics of early functional decline, termed "preclinical disability", the risk factors and underlying causes of preclinical disability and progression to disability and dependency and whether early decrements in physical functioning are predictive of future disability. The study was refunded in June 2000 through a competitive renewal of the R01 to conduct 3 more examinations over a 5-year period. We were granted a no cost extension which supports the study from 6/1/05 thru 5/31/06.