RESPIRATORY AND AROUSAL PATTERS IN NORMAL CHILDHOOD SLEEP

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。睡眠障碍在儿童中很常见，可导致严重后果，包括神经心理障碍、生长问题和心血管并发症。尽管儿科睡眠项目在全国各地如雨后春笋般涌现，但人们对儿童的正常睡眠知之甚少。睡眠模式随年龄而变化，因此，成人睡眠指数不足以衡量发育中儿童的睡眠问题。儿童的正常数据很少，只有一项针对少数年龄范围很广的儿童的研究。以前关于正常儿童的数据确定了预期的呼吸暂停指数（每小时呼吸暂停事件的数量），但在睡眠实验室中最常报告的是呼吸暂停低通气指数（AHI），这是呼吸紊乱的组合。儿童AHI的正常值未知。同样重要的是唤醒指数、周期性呼吸和反常呼吸的正常值，反常呼吸被认为是部分阻塞的迹象。由于睡眠异常的治疗是昂贵的，错过睡眠问题的成本是巨大的，确定什么是正常的是必不可少的。我们的具体目标是描述2-5岁儿童的呼吸和觉醒指数的变化。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Sleep disorders are common In children and can lead to severe consequences including neuropsychological disturbances, growth problems, and cardiovascular complications. Although pediatric sleep programs are springing up all across the country, little is known about normal sleep in children. Sleep patterns change with age, therefore, adult sleep indexes are inadequate for measuring sleep problems in the developing child. Normal data for children is sparse, with only one study on a small number of children with a very wide age range. Previous data on normal children determined the expected apnea index (number of apnea events per hour), yet what is most frequently reported in sleep laboratories is the apnea hypopnea index (AHI), a combination of respiratory disturbances. Normal values for the AHI are unknown in children. Equally important are normal values for arousal index, periodic breathing, and percentage of paradoxical breathing, thought to be a sign of partial obstruction. Since treatment of sleep abnormalities is costly, and the cost of missing sleep problems is great, determination of what is normal is essential. Our specific aim is to describe the percentiles of respiratory and arousal indices for children aged 2-5 years.