FAMILIAL DETERMINANTS OF HYPERTENSION

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。我们假设，我们将能够通过关注决定动脉压的生理途径来识别导致非裔美国人高血压的基因。该设计是一项病例对照研究，涉及高血压和血压正常的非裔美国人。该方案包括一次门诊就诊，在此期间获得以下信息：简史、标准化血压、人体测量；用于基础化学面板和DNA的外周静脉血。根据这些信息，符合纳入标准的受试者将被邀请参加相关的住院方案，这涉及到更广泛的表型鉴定。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We hypothesize that we will be able to identify genes contributing to hypertension in African Americans by focusing on physiological pathways that determine arterial pressure. The design is a case-control study involving hypertensive and normotensive African Americans. This protocol involves a single outpatient visit during which the following are obtained: brief history, standardized blood pressure, anthropometric measurements; peripheral venous blood for a basic chemistry panel and DNA. Based on thie information, subjects satisfying inclusion criteria will be invited to participate in a related inpatient protocol, which involves more extensive phenotyping.