FUNDAMENTALS OF FUNCTIONAL MRI

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。本研究将测试的假设，动态BOLD功能磁共振成像对比度血管和代谢成分随时间和空间的变化，并有足够的先验信息，测量特定方面的BOLD信号可以提供独特的信息，导致任务激活的生理事件。我们进一步假设，由于其机制的特异性，“灌注对比”功能磁共振成像技术将提供更好的生理空间的准确性和相应的神经元活动的幅度相关性。为了验证这一假设，本研究的主要目的是：1）研究静息血流量（CBF）、血容量（CBV）、氧摄取量和血管结构对BOLD信号的影响，2）确定与神经元激活相对应的fMRI信号的生理空间分辨率，3）研究神经元激活时的BOLD信号的空间分辨率。3）确定与神经元活动相关的fMRI信号的时间特征;以及4）确定人和动物脑中流量/BOLD的空间相关自发波动的生理（神经元）基础。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The present study will test the hypothesis that dynamic BOLD fMRI contrast has vascular and metabolic components that vary over time and space, and that with sufficient a priori information, measurement of particular aspects of the BOLD signal can provide unique information about the physiological events resulting from task activation. We further hypothesize that because of their mechanistic specificity, "perfusion contrast" fMRI techniques will provide improved physiological spatial accuracy and magnitude correlation corresponding to neuronal activity. To test this hypothesis, the following four specific aims will be addressed: 1) to characterize the influence of resting blood flow (CBF), blood volume (CBV), oxygen uptake and vascular architecture on the activation-induced BOLD signal; 2) to determine the physiological spatial resolution of the fMRI signal corresponding to neural activation; 3) to determine the temporal characteristics of the fMRI signal related to neuronal activity; and 4) to determine the physiological (neuronal) basis of spatially correlated spontaneous fluctuations in flow/BOLD in human and animal brain.