EFFECTS OF DIET ON ENDOTHELIAL FUNCTION

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。肱动脉血流介导的扩张（FMD）是一种测量血管内皮功能的非侵入性方法，血管内皮功能释放一氧化氮，从而引起动脉壁平滑肌松弛，导致血管扩张。这也与冠状动脉内皮的功能相关。在动脉粥样硬化风险和明显动脉粥样硬化的情况下，内皮的这种功能是钝化的。在本研究中，我们比较了低碳水化合物饮食或低脂饮食对导管血管功能的影响。为此，我们正在使用一种同样有效的减肥方案，使用传统的低脂饮食和低碳水化合物饮食，在不同的参与者中，并在六周内跟踪他们。我们假设，尽管两种不同类型的饮食都可以减肥，但低脂饮食会改善内皮功能，而低碳水化合物饮食会加剧内皮功能障碍。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Brachial artery flow-mediated dilation (FMD) is a non-invasive method of measuring the vascular endothelial function which is to release Nitric Oxide and thus cause a relaxation of the smooth muscle in the arterial wall leading to vascular dilation. This also correlates with the function of the coronary artery endothelium. This function of the endothelium is blunted in situations of atherosclerotic risks and also overt atherosclerosis. In this present study we compare the effects of a low carbohydrate diet or low-fat diet on conduit vessel function. For this we are using an equally effective weight reduction regimen using the traditional low-fat diet and a low carbohydrate diet, in separate participants and following them over a period of six weeks. We hypothesize that although both the different types of diets allow weight loss the low-fat diet will improve the endothelial function where as the low carbohydrate diet will intensify endothelial dysfunction.