LONGITUDINAL STUDIES OF PARKINSON'S DISEASE

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。1)。识别、招募特发性帕金森病（PD）患者，对其进行临床表征，并对其进行纵向随访，直至死亡，并对同意最终尸检的健康对照者进行随访，从而为PD研究中心（PDRC）项目#1-4中的神经病理学核心和神经病理学研究提供材料。临床特征将包括PD的运动、认知和精神特征的评估。将对管制进行可比的评估。2)。临床核心将与PDRC的行政核心和生物统计学家合作，开发和维护参与受试者的所有临床数据的计算机数据库，并为使用这些信息的中心研究提供持续的质量控制和统计支持。这些数据也将提供给JHMI的研究人员。3)。为帕金森病临床研究项目提供基础设施，促进独立资助的帕金森病临床和临床病理调查，并协调临床核心的纵向评估与受试者参与这些额外的研究。4)。培训医师-科学家在PD及相关疾病患者的临床评估和管理以及PD临床研究的表现。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. 1.) To identify, recruit, characterize clinically, and follow longitudinally until death patients with idiopathic Parkinson's Disease (PD) and healthy controls who consent to eventual autopsy, thereby providing material for the Neuropathology Core and the neuropathologic studies in Projects #1-4 of the PD Research Center (PDRC). Clinical characterization will involve assessment of the motor, cognitive, and psychiatric features of PD. Comparable assessments will be conducted on controls. 2.) In conjunction with the Administrative Core of the PDRC and the biostatistician, the Clinical Core will develop and maintain a computerized database of all clnical data obtained on participating subjects, and provide ongoing quality control and statisical support for studies in the Center gran using this information. These data will also be available to investigators with JHMI. 3.) To provide the fundamental infrastructure for a clinical research program on PD that facilitates independently funded clinical and clinical pathologica investigations of PD, and to coordinate the lingicudinal assessments by the Clinical Core with subject participation in these additional studies. 4.) To train physician-scientists in the clinical assessment and managment of patients with PD and related disorders and the performance of clinical research on PD.