ASTHMA AND RHINOSINUSITIS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。一项前瞻性队列研究，旨在确定哮喘的存在与上呼吸道疾病活动标志物之间的关系。哮喘患者的上、下呼吸道疾病之间存在密切的病理生理关系。然而，并不是所有的哮喘患者都报告鼻炎/鼻窦炎：我们预计那些没有症状的人可能只是患有亚临床疾病。我们将通过测量有和没有上呼吸道疾病症状的哮喘患者上呼吸道炎症标志物和功能变化来确定上呼吸道疾病是否为所有哮喘患者的特征。我们将把哮喘患者与正常的非哮喘患者进行比较。我们还将测量下呼吸道的炎症标志物和功能变化，以确定这些指标是否与上呼吸道疾病活动的标志物相关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A prospective cohort study to establish the relationship between the presence of asthma and markers of disease activity in the upper airway. There is a close pathophysiological relationship between the upper and lower airway disease that occurs in asthma. However, not all asthmatics report rhinitis/sinusitis: we anticipate those without symptoms may simply have subclinical disease. We will establish if upper airway disease is a characteristic of all asthmatics, by measuring inflammatory markers and functional changes in the upper airway of asthmatics with and without symptoms of upper airway disease. We will compare asthmatics to normal non-asthmatic subjects. We will also measure inflammatory markers and functional changes in the lower airway to determine if these measures correlate with markers of upper airway disease activity.