GENETIC DEFINITION AND PHENOTYPE DETERMINANTS OF HUMAN OVARIAN CARCINOMA

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。卵巢癌是美国女性癌症相关死亡的第四大原因。该项目通过以下方式解决卵巢癌问题：1）建立人类卵巢组织和临床数据库核心，以支持拟议的项目和未来的研究，2）鉴定卵巢癌中差异表达的基因，从而发现早期检测的生物标志物，3）研究从生殖系BRCA 1突变载体获得的卵巢组织中的卵巢肿瘤发生，以更好地理解BRCA 1突变失活之间的相互作用，细胞看守基因和细胞看门基因p53，和4）开发上皮性卵巢癌的遗传定义的小鼠模型。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Ovarian cancer is the fourth leading cause of cancer-related death in U.S. women. This program project approaches the ovarian cancer problem by 1) establishing a human ovarian tissue and clinical data base core facilitly to support the proposed projects and future investigations, 2) identifying genes which are differentially expressed in ovarian cancers and thereby discovering biomarkers for early detection, 3) studying ovarian tumorigenesis in ovarian tissues obtained from germline BRCA1 mututaion carrier to better understand the interaction between mutational inactivation of BRCA1, the cellular caretaker gene and p53, the cellular gatekeeper gene, and 4) developing a genetically defined mouse model of epithelial ovarian cancer.