ALOPECIA AREATA REGISTRY AND IMMUNOGENETIC MECHANISMS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。登记处的目的是：1)确定大量患有斑秃或更严重形式（全身性和普普通性脱发）的受试者。2)选择具有良好特征的特定人群，提供详细的临床数据、皮肤科医生检查、实验室研究、头皮数码照片、血清样本、白细胞和DNA。来自美国的具有明显特征的斑秃、AT或AU的个体患者、兄弟姐妹和多重家庭将被纳入研究。这些数据将被放置在一个关系数据库中，样本将被储存起来供未来的研究使用。3)为验证AA是一条多基因通路的假设提供数据和样本，并要求多个基因相互作用才能完全表达（AU/AT），外加一个环境触发因子。4)进行关联研究，比较AA不同表型中HLA等基因等位基因占比频率的差异。5)探讨AA在兄弟姐妹对和多患病个体的多重家族中的遗传标记。只有国家注册中心才能提供收集大量患者资料所需的资源。GCRC将通过提供临床可用性来帮助该项目，以容纳大量参与者，最大限度地减少参与登记的参与者的成本，并简化临床数据收集。这些数据仍将在德克萨斯州休斯顿的中心站点进行处理和分析。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of the Registry is: 1) To identify large numbers of subjects who have alopecia areata or more severe forms (alopecia totalis and universalis). 2) To select specific groups of well-characterized subjects for detailed clinical data, dermatoligist's exam, lab studies, digital photos of the scalp, sera samples, white blood cells, and DNA. Individual patients, sib-pairs, and multiplex families from the United States with well-characterized alopecia areata, AT or AU will be entered. Thte data will be placed in a relational database and the samples will be banked for future research studies. 3) To provide data and samples to test the hypothesis that AA is a multigenic trail and request the interaction of several genes for full expression (AU/AT) plus an environmental trigger factor. 4) To conduct association studies that compare differences in precent frequency of alleles of genes including HLA in the different phenotypes of AA. 5) To examine the inheritance markers with AA in sib-pairs and multiplex families with multiple affected individuals. Only a natinoal registry can provide the type of resources needed to collect this large number of patient material. The GCRC will aid this project by providing clinical availability to accomodate the large number of participants, minimize the cost to participants involved in the registry, and streamline the data collection in clinic. The data will still be processed and analyzed at the central site in Houston, TX.