REVERSAL OF EXERCISE-ASSOCIATED MENSTRUAL DISTURBANCE : PART 1

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本实验的目的是确定能量盈余的大小是否与运动闭经女性生殖轴的刺激直接相关。这项研究的结果将有助于为那些剧烈运动但没有摄入足够热量的女性提供实际的闭经逆转指导。拟议的实验不是为了记录月经的完全恢复，即通过提供额外的卡路里直到排卵和随后的月经发生。本实验将检查下丘脑-垂体-卵巢轴的短期反应，以便设计未来的实验，采用更长时间的治疗。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this experiment is to determine whether the magnitude of an energy surplus is directly related to the stimulation of the reproductive axis in women with athletic amenorrhea. The results of this study will be useful for providing practical guidelines for the reversal of amenorrhea in women who exercise strenuously but do not take in sufficient calories. The proposed experiment is not designed to document a complete recovery of menses, i.e. by providing extra calories until ovulation and subsequent menses occurs. This experiment will examine the short-term response of the hypothalamic-pituitary-ovarian axis in order to design future experiments that will employ treatments of longer duration.