GERIATRIC EXERCISE TRAINING FOR FITNESS (GETFIT)

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。50岁以上的美国艾滋病患者人数增加了5倍多。与年轻人相比，感染艾滋病毒的老年人预后更差。随着抗逆转录病毒治疗的进步和人口老龄化，感染艾滋病毒的老年美国人的数量将进一步增加，这清楚地表明需要与年龄相关的干预措施。关于年龄对艾滋病毒感染者功能表现的影响，以及运动训练是否能改善老年艾滋病毒感染者明显的身体脱条件，人们知之甚少。这项拟议研究的结果将开始确定衰老、艾滋病毒和并存疾病之间复杂关系的关键因素及其对身体功能的影响。我们将对90名21岁至50岁以上的艾滋病毒感染者进行横断面研究，以确定年龄对艾滋病毒感染者身体机能(最大有氧能力)和身体成分的影响。我们假设，老年艾滋病毒感染者的身体功能会加速下降，这在一定程度上可以通过运动康复干预来改变。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The number of Americans over age 50 with AIDS has increased more than 5-fold. Older adults with HIV have a worse prognosis than their younger counterparts. With advances in antiretroviral therapy, and the graying of the population, the number of HIV-infected older Americans will increase even further, clearly defining a need for age-related interventions. Little is known about the impact of age on functional performance in HIV-infected individuals and whether exercise training can ameliorate the marked physical deconditioning in older HIV-infected patients. Results from the proposed research will begin to identify the critical factors in the complex relationship of aging, HIV, and comorbid disease and their effect on physical functioning. We will conduct a cross-sectional study of 90 HIV-infected adults aged 21 to 50+ years to determine the effect of aging on physical functioning (peak aerobic capacity) and body composition in HIV-infected adults. We hypothesize that older HIV-infected individuals have an accelerated decline in physical functioning that is in part modifiable with exercise rehabilitation interventions.