NONINVASIVE VASCULAR DIAGNOSTIC DEVICE TO DISTINGUISH PREECLAMP FROM OTHR HYPERT

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。目的：妊娠期高血压疾病（HDP）包括先兆子痫（PE）、妊娠期高血压（GH）、潜在慢性高血压（CHTN）或合并CHTN的PE。大多数产妇和胎儿的发病率可归因于PE和严重不受控制的高血压的后果。PE通常很难与其他HDP区分，因为蛋白尿可能滞后于高血压的发病（Wolf, 2004）。本初步研究探讨了无创主动脉硬度指标（脉冲波速度，PWV和增强指数，AIx）在PE早期诊断中的应用。研究设计：从我们的分娩组中招募足月血压正常、足月CHTN和临床表现明显的PE（新发高血压和蛋白尿）初孕妇女。方法：采用无创压压式血压计（SphygmoCorTM）对仰卧位和坐位的桡动脉和颈动脉进行脉搏波分析（PWA）。心率变异性（HRV）在仰卧位时使用相同的设备通过ECG测定。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Purpose: The hypertensive disorders of pregnancy (HDP) include preeclampsia (PE), gestational hypertension (GH), underlying chronic hypertension (CHTN), or PE superimposed on CHTN. Most maternal and fetal morbidity may be ascribed to PE and to the consequences of severe uncontrolled hypertension. PE is often difficult to distinguish from other HDP, as proteinuria may lag behind onset of hypertension (Wolf, 2004). This pilot study investigates utility of non-invasive indices of aortic stiffness (pulse wave velocity, PWV and augmentation index, AIx) for early diagnosis of PE. Study Design: Normotensive at term, CHTN at term, and clinically apparent primigravid women with PE (new onset hypertension and proteinuria) are recruited from our labor and delivery suite. Methods: Pulse wave analysis (PWA) by noninvasive applanation tonometry (SphygmoCorTM) is performed at radial and carotid arteries in supine and sitting positions. Heart Rate Variability (HRV) is determined via ECG using the same device in the supine position.