CORE 2 DB4: PROTEASE PATHWAYS IN CAVEOLAE

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。驱动生物学项目4：内皮细胞小泡中的蛋白酶途径蛋白酶通常作为无活性酶原合成，然后被其他蛋白酶激活，作为级联反应的一部分。这些级联的蛋白质水解通常由区隔化促进。在过去的十年中，被称为小泡的质膜微域在调节细胞信号传导中的作用越来越明显。我们将测试小泡还有另一个作用的假设，即相互作用蛋白酶的区隔化

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Driving Biological Project 4: Protease Pathways Localized in Endothelial Cell Caveolae Proteases are frequently synthesized as inactive zymogens, and are then activated by another proteases, as part of a cascade. These cascades of proteolysis are frequently facilitated by compartmentalization. Over the last decade the role of plasma membrane microdomains, called caveolae, in regulating cell signaling has become increasingly apparent. We will test the hypothesis that caveolae have another role, the compartmentalization of interacting proteases