GENETICS OF SALT SENSITIVE HYPERTENSION

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。盐敏感性高血压的遗传学研究旨在检查盐敏感性高血压非洲裔美国同胞的遗传学，并进一步确定盐敏感性高血压的细胞和分子机制。500名患有1级和/或2级高血压的非洲裔美国同胞将接受低钠饮食，少于20 meq，持续1周。参与者将有一个完整的历史，身体和实验室评估，包括基因分型。如有必要，还将要求这些受试者停用当前的降压药物，并开始使用另一种药物（Adalat），持续3周。此后，指导患者停止所有抗高血压药物治疗，为研究的饮食阶段做准备，该阶段也将持续1周。在整个研究过程中，患者经常进行血压检查。在从研究中释放之前，对患者进行医学评估，并在必要时恢复研究前抗高血压药物治疗。将患者参与情况通知初级保健医生。大约350名对照参与者和兄弟姐妹的父母也被招募。他们的参与仅限于简短的病史、血压评估和/或抽血进行基因分型。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Genetics of Salt Sensitive Hypertension Study is designed to examine genetics in salt-sensitive hypertensive African-American siblings as well as to further define cellular and molecular mechanisms of salt-sensitive hypertension. 500 African-American sibships with stage 1 and/or 2 hypertension will receive a low sodium diet, less than 20 meq, for 1 week. The participants will have a complete history, physical and laboratory evaluation including genotyping. If necessary, such participants will also be asked to stop current anti-hypertensive medication and will be started on another (Adalat) for 3 weeks. After such, the patients are instructed to stop all anti-hypertensive medication to prepare for the diet phase of the study which will also last for 1 week. Throughout the study the patients have frequent blood pressure checks. Prior to release from the study, patients are medically evaluated and pre-study anti-hypertensive medication resumed, if necessary. Primary care physicians are notified of patient participation. About 350 control participants and parents of siblings in the study are recruited as well. Their participation is limited to a brief medical history, blood pressure evaluation and/or a blood draw for genotyping.