INSULIN AND SARCOPENIA IN THE ELDERLY

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。肌肉质量和力量随着年龄的增长而逐渐下降。这个过程被称为肌肉减少症，并且与福尔斯和骨折的风险增加有关，这增加了入住疗养院的风险。此外，肌肉质量和力量的减少可能导致身体活动减少，这可能具有包括骨质疏松、肥胖和糖尿病的可能影响。 具体目标和程序：1。比较健康老年人和年轻对照组之间肌肉对胰岛素的反应（生长和损失）。这将使我们能够测试的假设，肌肉蛋白质合成胰岛素的反应是受损的健康老年人。2.比较健康年轻志愿者和年轻2型糖尿病志愿者以及健康老年志愿者和老年2型糖尿病志愿者之间的葡萄糖和肌肉蛋白质周转（合成和分解）对胰岛素的反应。通过这种方式，我们将检验肌肉对胰岛素反应的缺陷仅与年龄相关而与糖尿病无关的假设。志愿者将通过IRB批准的广告招募，该广告将张贴在UTMB，当地报纸和社会中心，并通过口口相传。志愿者将被告知研究的风险和获益，并将被要求签署批准的知情同意书。 我们希望了解随着年龄的增长肌肉的损失是否是由于胰岛素在老年人中生长肌肉的能力的变化，以及这是否与糖尿病有关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Muscle mass and strength progressively decline with aging. This process has been termed sarcopenia, and is associated with increased risk of falls and bone fracture, which increase the risk of admission in nursing homes. Further, decreases in muscle mass and strength can lead to a reduction in physical activity, which may have possible effects including weak bone, obesity, and diabetes. Specific Aims and Procedures: 1. To compare the response of muscle (growth and loss) to insulin between healthy seniors and younger controls. This will allow us to test the hypothesis that the response of muscle protein synthesis to insulin is impaired in the healthy seniors. 2. To compare the response of glucose and muscle protein turnover (synthesis and breakdown) to insulin between healthy younger volunteers and younger type 2 diabetic volunteers, and between healthy senior volunteers and senior type 2 diabetic volunteers. In this way we will test the hypothesis that the defect in the response of muscles to insulin is only age-dependent and unrelated to diabetes. Volunteers will be recruited by an IRB-approved advertisement that will be posted at UTMB, local newspapers, and social centers, and by word of mouth. The volunteers will be informed about the risks and the benefits of the studies and will be asked to sign an approved consent form. We hope to learn if the loss of muscle with aging is due to changes in the ability of insulin to grow muscle in senior citizens, and if this is related or not to diabetes.