PILOT STUDY OF ARTIFICIAL GRAVITY AS A MULTI-SYSTEM COUNTERMEASURE TO BED REST

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项研究的目的是测试在长时间的太空飞行中，如何使用航天器旋转产生的力来取代重力。在这项研究中，将通过在人体离心机上旋转受试者来创造人造重力，并通过延长卧床时间来模拟太空飞行。对于研究人员来说，在没有重力的情况下进行太空旅行时，头部略微向下倾斜的卧床休息是模仿人的身体发生变化的好方法。在这项研究中，受试者将被限制在21天的24小时卧床休息，头部略微倾斜，体验宇航员在21天的失重太空飞行中身体经历的一些变化。在这21天里，受试者将不会下床；然而，每天一次，他们将被轮床推到离心机设施。在那里，处理对象将在离心机上旋转1小时，而对照对象将在不旋转的离心机上花费1小时。科学家们将在卧床前、卧床期间和卧床后测量许多身体系统的功能，以了解宇航员的身体在未来的太空飞行中将如何在失重状态下发生变化，以及如何利用人造重力来保护宇航员免受身体经历的一些变化。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to test how a force created by spinning the space craft could be used to replace gravity during long space flights. For this study, the ¿artificial gravity¿ will be created by spinning subjects on a human centrifuge and space flight will be simulated by prolonged bed rest. Bed rest with the head tilted down slightly below the feet is a good way for researchers to imitate the changes that occur in a person's body while traveling in space without gravity. In this study, subjects will be confined to 21 days of 24 hours a day bed rest, with the head tilted down slightly to experience some of the changes an astronaut's body goes through during 21 days of weightless space flight. During those 21 days subjects will not get out of bed; however, once a day they will be wheeled on a gurney to the centrifuge facility. There, treatment subjects will spend 1 hr spinning on the centrifuge and control subjects will spend 1 hr on the centrifuge without spinning. Scientists will measure the functioning of many of the body systems before, during, and after bed rest to learn how an astronaut's body will change in weightlessness during space flight in the future, and how artificial gravity might be used to protect astronauts from some of the changes their bodies go through.