EFFECTS OF AGE ON THE RESPONSE TO OXIDATIVE STRESS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。我们假设，在充气和收缩血压袖带引起的前臂缺血/再灌流后，血浆中自由基介导的脂质过氧化产物F2-异前列腺素水平的增加程度将提供对个体总抗氧化能力的准确评估，这在老年人中是受损的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We hypothesize that the extent to which levels of F2-isoprostanes, products of free radical mediated lipid peroxidation, increase in plasma following forearm ischemia/reperfusion induced by inflating and deflating a blood pressure cuff will provide an accurate assessment of an individual's total antioxidant capacity and that this is impaired in the elderly.