VENTRICULAR MYOCYTE FUNCTION IN HEALTH AND DISEASE

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。在过去的一年和加入Cobre以来，我的主要研究重点是研究糖尿病、高血压、肥胖和衰老中心脏兴奋-收缩(E-C)偶联异常和细胞生存/信号受损的病理生理学。我的工作主要集中在全心、单个心肌细胞的功能、细胞培养、细胞内钙稳态以及与一氧化氮和各种细胞应激相关的各种亚细胞信号通路。细胞生理学结合分子生物学、转基因和基因转移技术来了解这些疾病状态下的作用机制。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. My main research focus during the past year and since joining the COBRE has been to study the pathophysiology of abnormal cardiac excitation-contraction (E-C) coupling and impaired cell survival/signaling in diabetes, hypertension, obesity, and aging. My work focuses on whole heart, single ventricular myocyte function, cell culture, intracellular calcium homeostasis and various subcellular signaling pathways related to nitric oxide and various kinds of cell stress. Cellular physiology combined with molecular biology, transgene and gene transfer techniques are used to understand the mechanisms of action under these disease states.