COBRE: UD: PROJ 2: THE OSTEOARTHRITIC KNEE: A BIOMECHANICAL ANALYSIS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本研究的长期目标是确定异常关节接触力和应力在膝关节骨关节炎（OA）发展中的作用。要实现这一目标，必须首先实现几个短期目标。这些目标为提议的项目提供了框架，并为继续进行OA研究奠定了基础。该项目的五年目标是开发特定受试者的膝关节生物力学模型，该模型对关节几何形状和肌肉激活的学科间变化敏感，用于估计髌骨和胫股接触力学（即接触力和应力）。这是我们的论文，异常接触力学在日常生活活动（ADLs）与膝OA的发病和发展有关。本项目中创建的模型将用于建立健康受试者进行5种adl（行走、爬楼梯和下楼梯、从坐到站和从站到坐）时接触力和应力的正常范围。这些数据将被用作评估最近诊断为轻度OA的患者在进行类似运动时是否表现出异常的接触力学的参考。该项目的组织分为两个不同的目标，可以总结如下：目标1：目标1的目标是确定进行5次adl的健康受试者的髌股和胫股接触力学的正常范围。目的2：确定在疾病的早期阶段，是否大于正常的髌骨股骨和胫股接触力学是OA膝关节的特征。最近诊断为轻度OA但尚未出现慢性症状的个体的关节接触力学将使用Aim 1中概述的方法进行估计。我们的假设是，早发性骨性关节炎患者的接触力和压力比表现类似adl的健康个体大。在这些患者中显示大于正常的接触力和应力将支持我们的假设，即异常的接触力学与膝关节OA的发病和进展有关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The long-term goal of this research is to determine the role that abnormal joint contact forces and stresses contribute to the development of osteoarthritis (OA) of the knee. To achieve this goal, several shorter-term goals must first be realized. These goals provide the framework for the proposed project and the foundation for continued OA research. The five year goal of this project is to develop subject specific biomechanical models of the knee that are sensitive to inter-subject variations in joint geometry and muscle activations for the purposes of estimating patellofemoral and tibiofemoral contact mechanics (i.e., contact forces and stresses). It is our thesis that abnormal contact mechanics during activities of daily living (ADLs) are associated with the onset and progression of knee OA. The models created in this project will be used to establish normal ranges of contact force and stress for healthy subjects performing 5 ADLs (walking, stair ascent & descent, sit-to-stand & stand-to-sit). These data will then be used as a reference to assess if patients recently diagnosed with mild OA exhibit abnormal contact mechanics while performing similar movements. The organization of this project is divided into two distinct aims and may be summarized as follows: Aim 1: The goal of Aim 1 is to define normal ranges of patellofemoral and tibiofemoral contact mechanics for healthy subjects performaing the 5 ADLs. Aim 2: To determine if larger than normal patellofemoral and tibiofemoral contact mechanics are characteristic of the OA knee during the early stages of the disease. Joint contact mechanics for individuals recently diagnosed with mild OA, but not yet chronically symptomatic will be estimated using the approach outlined in Aim 1. It is our hypothesis that individuals with early onset OA will have larger contact forces and stresses than healthy individuals performing similar ADLs. Showing larger than normal contact forces and stresses in these patients would support our hypothesis that abnormal contact mechanics are associated with the onset and progression of knee OA.