GENETIC POLYMORPHISMS AND PREECLAMPSIA

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。背景：少数群体在生物医学领域的代表性明显不足。我们的假设是，部落大学生直接参与正在进行的、以当地为重点的生物医学研究工作，将增加学生对生物医学科学的兴趣和理解。子痫前期/子痫（P/E）是一种常见的妊娠并发症，具有严重的母婴后果。我们建议在美国印第安人（AI）人群中调查P/E的患病率和遗传危险因素与P/E的关系，他们是P/E的高风险人群。方法：一项病例对照研究（目标纳入：67例）将评估遗传多态性与子痫前期发展之间的关系。在龟山社区学院（Turtle Mountain Community College）建立的实验室中，受监督的学生将进行所有基因分型。最初的培训侧重于研究伦理，由首席研究员（PI）和一个全国认可的在线网站提供。已获得部落政府和所有相关内部审查委员会的批准。结果：研究伦理培训教育和敏感的那些参与知情同意过程的重要性和研究者的关键义务。在前4个月的积极招募中，共有37名参与者被招募。学生们为同学们举办了培训课程，并成功设计了标志、宣传小册子和海报。还完成了基因分析技术、实验室安全、普遍预防措施、HIPPA和隐私法方面的培训。学生们实地考察了马尼托巴省温尼伯的各种遗传实验室和社区卫生部门，从而看到了遗传原理在健康问题上的直接应用。学生们还参观了北达科他州大学，参观了正在进行的先兆子痫动物模型研究。结论：现在下结论还为时过早；但我们的希望是，这项研究将引起学生和社区成员对研究和生物医学领域的兴趣和教育。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Background: Minority groups are clearly under-represented within biomedical fields. Our hypothesis is that direct involvement of tribal college students in an ongoing, locally focused, biomedical research effort will increase student interest in and understanding of biomedical sciences. Preeclampsia/eclampsia (P/E) is a common complication of pregnancy that has serious maternal and fetal consequences. We propose investigation of the prevalence and relationship of genetic risk factors to P/E in an American Indian (AI) population who are at high risk to develop P/E. Methods: A case-control study (target enrollment: 67 cases) will assess the relationship between genetic polymorphisms and the development of preeclampsia. Supervised students in the laboratory, established at the Turtle Mountain Community College, will conduct all genotyping. Initial training has focused on research ethics, and is provided by the principal investigator (PI) and a nationally recognized, online website. Approvals have been obtained from the tribal government and all relevant IRBs. Results: The research ethics training has educated and sensitized those involved about the importance of the informed consent process and the critical obligations of investigators. A total of 37 participants have been enrolled during the first 4 months of active enrollment. Students have conducted training sessions for fellow students and successfully designed a logo, an informational pamphlet and poster. Training has also been completed on genetic analysis techniques, lab safety, universal precautions, HIPPA, and Privacy Act. A field trip to various genetic laboratories and the Community Health Department in Winnipeg, Manitoba allowed the students to see direct application of genetic principles to health problems. Students also visited the University of North Dakota and saw ongoing animal-model research in preeclampsia. Conclusions: It is premature to offer conclusions; but our hope is that this research study will interest and educate both students and community members about research and biomedical fields in general.