MS INBRE: BIOINFORMATICS CORE

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。MFGN生物信息学核心（BC）为密西西比科学家和学生提供三大服务。第一个是一个网络可访问的序列分析工具套件。欧洲分子生物学开放软件套件（European Molecular Biology Open Software Suite）允许我们的客户从该州的任何地方访问软件，分析和存储MFGN服务器上的序列数据。核心提供的第二个主要服务是微阵列数据分析。这些努力包括微阵列数据的统计分析和管理，基因组学、蛋白质组学和代谢组学数据的分析，以及生物信息学工具的开发。核心提供的第三项服务是生物数据库设计。这些努力是通过招聘计算生物学家Youping Deng博士进入终身职位而实现的。邓博士是生物信息学专家，并担任MFGN生物信息学核心的副主任。目前正在利用生物信息学的核心设施和专业知识进行11个以上的项目。 另一个正在进行的核心项目是在PUI机构安装接入网格节点。核心是使用NCRR授予的补充来增加PUI的带宽，这对于使活动星系核在线至关重要。还将向所有PUI提供Internet 2，这将使他们能够充分参与MFGN的网络和指导活动。这些努力因卡特里娜飓风而暂时推迟。Bellsouth（互联网服务提供商）和相关校园的IT人员（USM和PUI）需要时间来修复飓风造成的破坏，然后才能继续项目工作。我们高兴地报告，因特网2升级工作已回到正轨。所有必要的硬件都已订购，所有相关的IT部门都已完成并批准了计划。我们预计该项目将于2006年3月完成。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The MFGN bioinformatics core (BC) provides three major services to Mississippi scientists and students. The first one is a web-accessible suite of sequence analysis tools. EMBOSS (European Molecular Biology Open Software Suite) allows our clients to access the software from anywhere in the state, analyze and store sequence data on MFGN servers. The second major service offered by the core is microarray data analysis. These efforts include statistical analysis and management of microarray data, analysis of genomic, proteomic and metabolomic data, and development of bioinformatics tools. The third service offered by the core is biological database design. These efforts have been made possible by the recruitment of a computational biologist, Dr. Youping Deng, into a tenure track position. Dr. Deng is an expert in bioinformatics and acts as associate director of the MFGN bioinformatics core. More than eleven projects are currently underway utilizing the bioinformatics core facilities and expertise. Another ongoing project at the core is the installation of access grid nodes (AGNs) at the PUI institutions. The core is using the supplement awarded by NCRR to increase bandwidth at the PUIs, which is essential for bringing the AGNs on-line. All PUIs will also be provided with Internet2, which will allow them to fully participate in the networking and mentoring activities of MFGN. These efforts were temporarily delayed due to Hurricane Katrina. Bellsouth (internet service provider) and IT personnel at the campuses involved (USM and PUIs) needed time to repair damage caused by the hurricane before continuing work on the project. We are pleased to report that work on the Internet2 upgrade is back on track. All the necessary hardware has been ordered, and plans are finalized and approved by all of the IT departments involved. We expect the project to be completed by March 2006.