PATHOPHYSIOLOGY OF ATM & P53

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。杨博士研究生长因子的信号转导和蛋白质翻译起始机制。他的研究重点是两个重要的蛋白质，ATM和p53，这两个蛋白质在细胞周期进程、DNA损伤修复、神经元变性和胰岛素抵抗等多种生理过程中至关重要。他的目标是了解ATM激酶如何在不同类型的细胞中对生长因子和细胞毒性应激作出反应。他还研究了p53肿瘤抑制因子的翻译是如何在DNA损伤信号的响应中受到调节的。杨博士将与奥格拉拉拉科塔学院的Sandoval博士就植物提取物对糖尿病大鼠的影响进行合作研究。为这一合作购买动物和用品的工作正在进行中。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Dr. Yang studies signal transduction of growth factors and the mechanism of protein translation initiation. His research focuses on two important proteins, ATM and p53, which are critical for multiple physiological processes such as cell cycle progress, DNA damage repair, neuronal degeneration, and insulin resistance. His goal is to understand how ATM kinase functions in various types of cells in response to growth factors and cytotoxic stresses. He also examines how translation of p53 tumor suppressor is regulated in response to DNA damage signals Dr. Yang will be carrying out a collaborative study with Dr. Sandoval from Oglala Lakota College on the effects of the plant extract on diabetic rats. The purchase of animals and supplies for this collaboration is in process.