NEUROHUMORAL CONTROL OF CARDIOVASCULAR FUNCTIONS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。李博士的实验室研究心血管功能的神经体液控制，包括中枢自主神经通路中神经递质/调节剂的相互作用，以及心血管疾病（包括心力衰竭和糖尿病）中自主神经功能改变的中枢机制。他们还研究下丘脑内神经递质/调节剂在内分泌调节中的相互作用及其在生理和病理生理条件下调节心血管功能的作用。他们对神经免疫调节特别感兴趣，因为它适用于细胞因子产生和释放的自主调节及其在心血管疾病中的作用，以及细胞因子对神经内分泌功能的中枢和外周作用及其在心血管功能调节中的作用，包括正常和患病心脏的形态学。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Dr. Li's laboratory studies neurohumoral control of cardiovascular functions including interactions of neurotransmitters/modulators in central autonomic pathways and central mechanisms involved in altered autonomic functions in cardiovascular diseases including heart failure and diabetes. They also study interactions of neurotransmitters/modulators within the hypothalamus in endocrine regulations and their roles in regulation of cardiovascular functions in physiological and pathophysiological conditions. They are particularly interested in neuroimmunoregulation as it applies to autonomic regulation of cytokine generation and release and their roles in cardiovascular diseases and in central and peripheral actions of cytokines on neuro-endocrine functions and their roles in regulation of cardiovascular functions including the morphometry of normal and diseased hearts.