MISSISSIPPI COBRE: CORE B: CHEMISTRY CORE

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。目的：天然产物神经科学卓越研究中心化学核心的主要目标是分离，表征和优化具有潜在神经系统活性的植物，细菌，真菌和海洋生物的活性成分。该核心将负责阐明结构，并为体外和体内药理学研究提供材料，以开发新的精神药物候选物和研究神经系统功能的研究工具。化学核心还将为需要基于天然产物的药物先导和原型的分离，结构解析和先导优化专业知识的单个项目提供咨询服务。化学核心的专业知识包括：（a）以毫克至公斤的规模分离和纯化活性次级代谢物，（B）分离的活性成分的结构解析，（c）重新分离或合成大量活性成分用于体外和体内研究，以及（d）对先导化合物进行半合成修饰，以生成SAR数据并进一步开发候选药物。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objectives: The major aims of the Chemistry Core of the Center of Research Excellence in Natural Products Neuroscience are to isolate, characterize and optimize the active principles of plants, bacteria, fungi, and marine organisms with potential nervous system activity. This core will be responsible for the elucidation of structures and provide material for in vitro and in vivo pharmacological studies in order to develop new psychotropic drug candidates and research tools to study nervous system function. The Chemistry Core will also have an advisory role for individual projects that require expertise in the isolation, structure elucidation and lead optimization of natural products based drug leads and prototypes. The expertise of the Chemistry Core includes: (a) isolation and purification of active secondary metabolites on a mg to kg scale, (b) structure elucidation of isolated active principles, (c) re-isolation or synthesis of larger quantities of active components for in vitro and in vivo studies, and (d) semi-synthetic modification of lead compounds to generate SAR data and to further develop drug candidates.