Role of TFII-I in Craniofacial Development

描述（由申请人提供）：该独立科学家奖（K02）申请是基于申请人最近从NIDCR （DE 017205）获得的2006-2010年NIH R01奖。父母R01奖题为“TFII-I在颅面发育中的作用”，讨论了TFII-I转录因子在颅面发育中的功能。本次K02申请的“研究计划”部分提出的拟研究与原R01申请中提出的研究相比，没有明显的变化，除了在此之后取得的一些进展被纳入本申请的初步数据部分。在最初的R01申请中提出的研究方法和实验设计很大程度上基于申请人在小鼠遗传学和分子生物学方面的科学训练和专业知识。申请人充分认识到多学科对进行有竞争力和高质量的研究的重要性，这是成功的科学事业所必需的。因此，申请人计划获得额外的专业知识并学习新的系统，以将原始提案提升到更高的水平，并扩大首席研究员在功能筛选，蛋白质生物化学和蛋白质组学以及系统生物学方面的科学专业知识。在候选人的“职业发展计划”的以下部分描述了细节和基本原理。

DESCRIPTION (provided by applicant): This Independent Scientist Award (K02) application is based on the applicant's recently funded NIH R01 award from NIDCR (DE 017205) for the years of 2006-2010. The parental R01 award entitled "Role of TFII-I in Craniofacial Development" addresses the function of the TFII-I transcription factor in orofacial development. The proposed research presented in the "Research Plan" section of this K02 application does not have significant changes compared with the studies proposed in the original R01 application, except that some progress made since then is incorporated in the preliminary data section of this application. The research approaches and experimental design proposed in the original R01 application are largely based on the applicant's scientific training and expertise in mouse genetics and molecular biology. The applicant fully realizes the importance of multi-discipline in conducting competitive and high quality research, which is essential for a successful scientific career. Therefore, the applicant plans to acquire additional expertise and learn new systems to promote the original proposal to a higher level and extent the principal investigator's scientific expertise in functional screening, protein biochemistry and proteomics, and systems biology. The details and rationale are described in the following section of the candidate's "career developmental plan".