GENETIC ANALYSIS TECHNIQUES FOR COMMON CANCERS

描述（由申请人提供）：该计划的长期目标是使候选人成为癌症预防和控制方面的独立，负责任和富有成效的学术研究人员，具体目标是确定参与常见癌症的易感性，风险修饰或生存的基因。 将通过开发和应用新的方法来具体实现基因鉴定的目标。 候选人的近期职业目标是实现职业重心的转变， 癌症研究，主要通过与独特的犹他州癌症资源合作， 开发针对这些资源的方法。 职业发展计划包括课程（癌症生物学和遗传学、流行病学、生物伦理学、管理和方案编制）;参加相关研讨会;指导阅读;课程编制;参加讲习班和科学会议;指导研究培训，包括针对具体疾病的培训和方法学培训;以及方法学和与癌症有关的合作。 这些活动将补充和发展候选人现有的技能、知识和经验。 所提出的研究计划与许多遗传流行病学研究领域有关， NCI已经强调了重要性，包括癌症的遗传易感性，癌症生存率， 和生物统计学。 该提案的具体目标是开发和执行新的方法 用于分析家族性、疾病关联和生存，以及常见的 癌的 此外，候选人将研究确定适当的 这些分析的显著性阈值。 这些职业发展活动和研究计划的结合将有助于候选人的 实现短期和长期职业目标，同时也促进 癌症研究的进步。

DESCRIPTION (provided by applicant): The long-term objectives of this proposal are to enable the candidate to become an independent, responsible and productive academic researcher in cancer prevention and control, with a specific goal to identify genes involved in the pre-disposition, risk modification or survivorship of common cancers. The objective towards gene identification will be pursued specifically through the development and application of novel methodologies. The candidate's immediate career goals are to implement a change in career focus to concentrate on cancer research, facilitated by working primarily with unique Utah cancer resources and developing methodologies specific to these resources. The career development plan consists of coursework (cancer biology and genetics, epidemiology, bio-ethics, management and programming); attendance at relevant seminars; directed readings; curriculum development; participation at workshops and scientific meetings; mentored research training, both disease-specific and methodologic; and methodological and cancer-related collaborations. These activities will complement and develop the current skills, knowledge and experience of the candidate. The research plan proposed is relevant to many genetic epidemiologic research areas that the NCI has highlighted as important, including genetic predisposition to cancer, cancer survivorship, and biostatistics. The specific aims of this proposal are to develop and perform novel methodologies for the analysis of familiality, disease association and survival, and genetic linkage for common cancers. In addition, the candidate will investigate methods for the determination of appropriate significance thresholds for these analyses. The combination of these career development activities and research plan will aid the candidate's development towards the achievement of short- and long-term career goals, while also contributing to the advancement of cancer research in general.