Hearing protection conferred by P2X2 receptor signaling in the cochlea

噪声损伤和衰老导致的听力损失是我们社会的主要感官残疾。该项目将确定P2X2受体在保护噪声引起的听力损失中的作用。我们发现，P2X2基因敲除小鼠有最小的暂时性阈值漂移。我们将研究这一现象的生理学基础，并确定为什么与野生型对照相比，这种小鼠模型具有更大的听力损失和更快的与年龄相关的听力损失。

Hearing loss from noise damage and ageing is the principal sensory disability in our society. This project will determine the contribution of the P2X2 receptor to protection from noise-induced hearing loss. We have found that P2X2 knockout mice have minimal temporary threshold shift. We will investigate the physiological basis for this and determine why this mouse model has greater hearing loss with intense sound and faster age-related hearing loss compared with wildtype controls.