An Ultra High Resolution MRI-Compatible SPECT System

描述（由申请人提供）：在这项拟议的研究中，我们将开发一个原型非常高分辨率的MR-兼容SPECT系统，该系统将安装在现有的4.7特斯拉瓦里安MRI扫描仪中，并允许使用SPECT和MRI模式进行非常高分辨率的小鼠脑成像。该系统可用于高分辨率的小鼠脑SPECT和MR成像研究。这将大大有利于UIUC正在进行的脑肿瘤免疫治疗研究。这种兼容核磁共振的SPECT系统是基于我们目前正在开发的一种新型能量分辨光子计数（ERPC）混合像素传感器的非常高分辨率成像传感器。在固定环配置中使用多个检测器模块，这允许在不移动SPECT系统的情况下进行足够的角度采样。在这个R21项目中，原型核磁共振兼容SPECT系统由三个ERPC探测器模块组成，安装在瓦里安核磁共振扫描仪直径33厘米的孔内。该系统的主要设计目标是允许同时采集数据，并在两种模式下提供相当的成像分辨率（SPECT 250-400um, MRI 100-200）。半导体探测器的使用允许同时使用多种示踪剂，如Tc-99m， I-125等，这进一步提高了该SPECT/MRI双模成像系统的通用性。这项R21计划的工作将集中在(a)开发一个三重SPECT系统，(b)将SPECT系统与现有的4.7T MRI系统集成，以及(c)评估用于幻影成像研究的原型双模系统。特别是，大量的努力将致力于减少同时操作的SPECT和MRI系统之间的干扰。这项R21研究将通过一个完整的核磁共振兼容的非常高分辨率SPECT系统的设计研究来结束。公共卫生相关性：高分辨率核磁共振兼容SPECT系统将专门用于体内SPECT/MRI双模成像。它提供了与SPECT和MRI同时获得的非常高分辨率的图像，将被证明对使用小鼠模型进行脑癌研究很重要。这一进展将大大有利于UIUC正在进行的脑肿瘤免疫治疗研究。

DESCRIPTION (provided by applicant): In this proposed investigation, we will develop a prototype very high resolution MR- compatible SPECT system that will be installed inside a pre-existing 4.7 Tesla Varian MRI scanner and allows for very high resolution, simultaneous mouse brain imaging using both SPECT and MRI modalities. This system is optimized for very-high resolution simultaneous SPECT and MR imaging study of mouse brain. It would substantially benefit the on-going research at UIUC for developing immunotherapy for brain tumors. This MR-compatible SPECT system is based on a very high resolution imaging sensor based on a novel energy resolved photon counting (ERPC) hybrid pixel sensor that we are currently developing. Multiple detector modules are used in a stationary ring configuration, which allows a sufficient angular sampling without moving the SPECT system. In this R21 project, the prototype MR-compatible SPECT system consists of three ERPC detector modules, fitted inside the 33cm diameter bore of the Varian MRI scanner. The major design goals of this system are to allow simultaneous data acquisition and to offer comparable imaging resolution (250-400um from SPECT and 100-200 from MRI) with both modalities. The use of the semiconductor detector allows the use of multiple tracers, such as Tc-99m, I-125 etc, at the same time, which further improve the versatility of this SPECT/MRI dual-modality imaging system. This proposed R21 effort will be focused on (a) develop a triple-headed SPECT system, (b) integration of the SPECT system with an existing 4.7T MRI system and (c) evaluate the prototype dual modality system for phantom imaging studies. In particular, substantial efforts will be dedicated to minimize the interferences between the simultaneously operated SPECT and MRI systems. This proposed R21 investigation will be concluded by a design study for a complete MR-compatible very-high resolution SPECT system. PUBLIC HEALTH RELEVANCE: The very-high resolution MR-compatible SPECT system will be dedicated to in vivo SPECT/MRI dual-modality imaging. It offers very-high resolution images simultaneous acquired with both SPECT and MRI, will is proven to be important for brain caner study using mouse models. This development will substantially benefit the on-going research at UIUC on developing immunotherapy for brain tumors.