Novel MRI and 1H-MRS markers in Primary Progressive MS

四页） 其他个人简介（每份不超过四页-见说明） 资源33 研究计划。33 修改后的申请简介（不超过3页）33 补充申请简介（不超过一页）N/A A.具体目标36 B。背景与意义37 C.初步研究/进度报告/（项目A-D：不超过25页 *）44 第I阶段进度报告（仅限SBIR/STTR第II阶段）* SBIR/STTR第I阶段：A-D项限制为15页。 D.研究设计与方法50 E.人类受试者58 人类受试者保护（如果正面页面上的第4项标记为“是”，则需要）58 纳入女性（如果正面页面上的项目4标记为“是”，则需要）_58 包括少数民族（如果首页上的项目4标记为“是”，则为必填项）_58 包括儿童（如果正面页面上的第4项标记为“是”，则需要）58 数据和安全性监测计划（如果正面页面上的第4项标记为“是”，则需要提供I、II或III期临床试验） 建议试用 F.脊椎动物60 G.引用文献60 H.联营集团/合同安排 I.支持信（例如，顾问）68 J.产品开发计划（仅SBIR/STTR第二阶段和快速通道）N/A 清单。69 检查是否 附录（五个整理集。附录所需的页码编号。） 阑尾是 包括 附录不允许用于第I阶段SBIR/STTR，除非特别征求…… 出版物和被接受出版的手稿数量（不超过10份） 其他项目（列表）： 1.支持信：John DeLuca教授，顾问 PHS 398（修订版05/01）第页。第3页 使用/2英寸边缘。在整个应用程序的底部连续编号页面。不要使用后缀，如3a，3b。

four pages) Other Biographical Sketches (Not to exceed four pages for each - Seeinstructions) Resources 33 Research Plan. 33 Introduction to Revised Application (Not to exceed 3 pages) 33 Introduction to Supplemental Application (Not to exceed one page) N/A A. Specific Aims 36 B. Background and Significance 37 C. Preliminary Studies/Progress Report/ (Items A-D: not to exceed 25 pages*) 44 Phase I Progress Report (SBIR/STTR Phase II ONLY) * SBIR/STTR Phase I: Items A-D limited to 15 pages. D. Research Design and Methods 50 E. Human Subjects 58 Protection of Human Subjects (Required if Item 4 on the Face Page is marked "Yes") 58 Inclusion of Women (Required if Item 4 on the Face Page is marked "Yes") _58 Inclusion of Minorities (Required if Item 4 on the Face Page is marked "Yes") _58 Inclusion of Children (Required if Item 4 on the Face Page is marked "Yes") 58 Data and Safety Monitoring Plan (Required if Item 4 on the Face Page is marked "Yes" and a Phase I, II, or III clinical trial is proposed F. Vertebrate Animals 60 G. Literature Cited 60 H. Consortium/Contractual Arrangements 66 I. Letters of Support (e.g., Consultants) 68 J. Product Development Plan (SBIR/STTR Phase II and Fast-Track ONLY) N/A Checklist. 69 Check if Appendix (Five collatedsets. Nopage numbering necessary for Appendix.) Appendix is Included Appendices NOT PERMITTED for Phase I SBIR/STTR unless specifically solicited.... Number of publications and manuscripts accepted for publication (notto exceed10) Other items (list): 1. Letter of support: Prof. John DeLuca, consultant PHS 398 (Rev. 05/01) Page. Form Page 3 Use /2-inch MARGINS. Number pages consecutively at the bottom throughout the application. Do not use suffixes such as 3a, 3b.