Temperature-activated TRP channels and thermosensation

近年来，感觉神经生物学的分子描述取得了巨大进展。在视觉、听觉、味觉、嗅觉和触觉这五种普遍具有特征的感官中，触觉是最多样化的，也许也是最不为人所知的。在这种形态中是感知的能力

Recent years have seen great advances in the molecular description of sensory neurobiology. Of the five popularly characterized senses - sight, hearing, taste, smeli, and touch - touch is among the most varied and perhaps least understood. Within this modality is the ability to sense mechanical forces, chemical stimuli, and temperature, and the molecules that mediate this ability have been a long-standing mystery. My group and others have recently discovered ion channels that are activated by different thresholds of temperature, and might enable sensory neurons to convey temperature information. Among these ion channels is TRPV3, which senses warm temperatures and is expressed in the skin. Here we use genetic and biochemical tools to test if TRPV3 and its close homologs play an essential role in thermosensation and pain.