FOLLOWING THE FATE OF HCMV GENE PRODUCTS IN HOST CELLS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。巨细胞病毒广泛传播于所有地理位置和社会经济群体，到40岁时感染美国85%的成年人。我们的目的是研究人类巨细胞病毒衍生物与细胞蛋白的相互作用，这将为分析疱疹病毒调控的细胞通路提供见解。我们已经分离了带有蛋白A或GFP标记的HCMV病毒蛋白，并在感染的不同阶段与宿主和病毒相互作用的伙伴进行了分离。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cytomegalovirus is widely spread throughout all geographic locations and socioeconomic group and infects 85% of adults in United States by 40 years of age. Our aim is to study the interactions of human cytomegalovirus derivatives with cellular proteins, which would give insights towards the analysis of cellular pathways modulated by herpesviruses. We have isolated Protein A- or GFP-tagged HCMV viral proteins with their host and viral interacting partners at various stages of infections.