Northwest/Alaska Cent. to Reduce Oral Health Disparities

该提案是对RFD DE-99-003的回应，旨在建立西北和阿拉斯加口腔健康差异研究中心，以减少太平洋西北地区和阿拉斯加的口腔健康差异。建议该中心发展基础知识和应用知识，以解决贫困、少数民族和农村儿童及其照顾者的需求，利用超越传统牙科公共卫生战略的方法，这些方法在这些人群中尚未取得成功。虽然拟议中心的研究可能涉及传统的牙科人员，但它也强调儿科医生、母亲和儿童的作用；以及氟化物以外的预防剂。参与者包括阿拉斯加土著居民、亚基马印第安民族的土著美国人、来自华盛顿农业区的西班牙裔美国人、来自当地军事保留地的非洲裔美国人和西班牙裔美国人、城市医院服务的西班牙裔和太平洋岛民以及农村和低收入白人。我们建议通过五个具体目标来实现这一目标：(1)通过开展临床研究来评估非传统干预措施在预防和治疗儿童及其照顾者口腔疾病方面的效果，以满足太平洋西北地区和阿拉斯加的需求；(2)开展以社区为基础的研究，将有关儿童及其照料者的现有知识和新信息转化为有望减少这些高危人群差距的新技术和干预措施；(3)通过与该地区主要的少数民族教育和卫生服务机构合作，扩大太平洋西北地区和阿拉斯加少数民族人口的卫生科学教育和研究培训机会；(4)开展基础研究，进一步了解宿主防御机制和遗传基础在服务不足人群龋齿和牙周病中的作用，探索抗菌药物改变疾病易感性的生物学基础；(5)通过从太平洋西北地区和阿拉斯加的少数民族机构招募调查人员和学生，优先考虑和鼓励他们参与的试点研究和中心附属研究，增加中心在本提案所包括项目之外的影响。合作机构和合作伙伴是遗产学院（位于亚基马印第安民族的西班牙裔和印第安人服务机构）、阿拉斯加土著部落健康联盟/育空-库斯科维姆土著健康公司、亚基马山谷农场工人诊所、西北波特兰地区印第安人健康委员会/西北部落流行病学中心、华盛顿牙科服务基金会（主要的私人牙科保险公司）；医疗援助管理局（华盛顿州医疗补助机构）。

This proposal is in response to RFD DE-99-003 to establish the Northwest and Alaska Center for Oral Health Disparity for research to reduce oral health disparities in the Pacific Northwest and Alaska. It is proposed that the Center develop basic and applied knowledge that addresses the needs of poor, minority, and rural children and their caretakers, utilizing approaches that go beyond the traditional strategies from dental public health that have not found success in these populations. While the research in the proposed center may involve traditional dental personnel, it also stresses the roles of pediatricians, mothers as well as children; and preventive agents beyond fluorides. Participants include Alaska Natives, Native Americans from the Yakima Indian Nation, Hispanics from the agricultural areas of Washington, African Americans and Hispanics from the local military reservations, Hispanics and Pacific Islanders served by urban hospitals as well as rural and low-income Whites. We propose to accomplish this goal through five specific aims: (1) To address the needs of the Pacific Northwest and Alaska by conducting clinical research to evaluate the efficacy of non- traditional interventions to prevent and treat oral disease in children and their caretakers; (2) To develop community-based research that translates existing knowledge and new information regarding children and their caretakers into new technologies and interventions that hold promise for reducing disparities in these high risk populations; (3) To expand health science education and research training opportunities for minority populations in the Pacific Northwest and Alaska by collaborations with key minority educational and health serving institutions in the region; (4) To conduct basic research to further understand the role of host defenses and genetic bases for caries and periodontal disease affect underserved populations as well as to probe the biologic basis for antibacterial that change disease susceptibility; and (5) To increase the impact of the center beyond the projects included in this proposal by recruiting investigators and students from minority institutions in the Pacific Northwest and Alaska and prioritizing and encouraging pilot and center-affiliated studies in which they are involved. The collaborating institutions and partners are Heritage College (Hispanic and Native American-serving institution sited on the Yakima Indian Nation), Alaska Native Tribal Health Consortium/Yukon-Kuskokwim Native Health Corporation, Yakima Valley Farm Workers Clinic, Northwest Portland Area Indian Health Board/Northwest Tribal Epidemiology Center, Washington Dental Service an Foundation (major private dental insurer); and Medical Assistance Administration (Medicaid agency for Washington State).