Genetics Of Drug Resistance, Antigenic Variation And Dis

我们的研究项目侧重于疟疾中抗药性、免疫逃避和疾病毒力的决定因素。调查的重点是恶性疟原虫，这是导致人类最严重疟疾的寄生虫。主要项目包括：(1)确定疟疾寄生虫抵抗氯喹和奎宁等药物的分子机制；(2)恶性疟原虫在疟疾中的传染性和致病力的遗传学；(3)疟疾寄生虫抗原变异和人体免疫系统逃避的相关基因的特征；(4)研究血红蛋白C和S对恶性疟疾的保护作用。我们的项目包括实验室的基础研究以及疟疾地区的实地研究。这项工作的实际目标是为疟疾诊断和治疗的发展提供基本信息。

Our research program focuses on determinants of drug resistance, immune evasion, and disease virulence in malaria. Investigations center on Plasmodium falciparum, the parasite that causes the most severe form of human malaria. Major projects include: (1) identification of the molecular mechanims by which malaria parasites resist such drugs as chloroquine and quinine; (2) genetics of Plasmodium falciparum infectivity and virulence in malaria; (3) characterization of the the genes responsible for malaria parasite antigenic variation and evasion of the human immune system; (4) studies of the protection conferred by hemoglobins C and S against the severe forms of falciparum malaria. Our projects involve basic research in the laboratory as well as field studies in malarious regions. Practical goals of the work are to provide fundamental information for the development of diagnostics and therapeutics against the malaria.