Bioactive Biodegradable Nano-Composite (BBNC) Materials for Regnerative Medicine

整形外科研究单位将评估人类细胞对可生物降解纳米复合材料的反应。这将决定这些材料是否能够支持导致骨形成的细胞功能，以及是否存在主动的细胞去除材料。这项工作还旨在了解这些材料的生物反应背后的机制。选定的纳米复合材料将通过植入和测量其支持骨形成的能力进行评估。将测量它们与骨相互作用的机械强度和随后的降解率。这些结果将使这些材料用于特定功能的适宜性得到评估，例如作为骨折固定的棒和板，或者作为将受损的骨连接在一起的螺钉，并表明这些材料比目前的材料具有优势。

The Orthopaedic Research Unit will evaluate the response of human cells to the biodegradable nano-composite materials. This will determine whether these materials can support cellular functions leading to bone formation and whether there is active cellular removal of the material. This work also aims to understand the mechanisms behind the biological response to these materials. Selected nano-composites will be assessed by implantation and measurement of their ability to support bone formation. The mechanical strength of their interaction with bone and their subsequent rate of degradation will be measured. The results will allow the suitability of these materials for particular functions, for example as rods and plates for fracture fixation or as screws for holding damaged bone together, to be assessed and indicate advantages over current materials.