Implantable glucose sensor with prolonged accuracy

描述（由申请人提供）：本研究的目标是制造一种在体内准确工作7天的血管内葡萄糖传感器。我们将利用第一阶段设计的葡萄糖膜设计来开发一种定制的外膜，该外膜具有共价附着的生物活性位点，以抵抗生物污染，允许适当的葡萄糖扩散，并防止潜在有毒副产物的浸出。该膜将应用于针式、安培式葡萄糖传感器。传感器设计的多功能性将允许通过中心导管轻松整合到患者的血液中。该导管将设计为在重症监护病房使用7天，并将完成止血连接器，用于连接到访问线，以及与放大器/显示单元的电气连接。最终的原型将使用体外和体内方法评估细胞毒性、血液相容性和准确性。持续监测血糖水平一直是一个难以实现的目标，但在管理胰岛素治疗方面将大大改善对危重病人的护理。公共卫生相关性：本资助的目标是制造一种连续7天测量血糖水平的血管内血糖传感器。通过保持传感器功能，该技术将为医疗保健专业人员提供患者健康状况的即时变化并减少并发症。目前没有检测到血糖水平的突然变化，导致医疗费用增加和患者风险增加。

DESCRIPTION (provided by applicant): The goal of this study is to fabricate an intravascular glucose sensor that functions accurately for 7 days in vivo. We will utilize a glucose membrane design devised in Phase I to develop a custom outer membrane that has covalently attached bioactive sites to resist biofouling, allows for suitable glucose diffusion, and prevents leaching of potentially toxic by-products. This membrane will be applied to needle-type, amperometric glucose sensor. The versatility of the sensor design will allow easy incorporation into a patient's bloodstream through a central access catheter. The catheter will be designed for 7 day use in the intensive care unit, and will be complete with a hemostatic connector for attaching to an access line, and the electrical connections to an amplifier/display unit. The final prototype will be evaluated for cytotoxicity, hemocompatibilty, and accuracy both using in vitro and in vivo methods. Continuous monitoring of blood glucose levels has been an elusive goal, but would greatly improve the care for critically ill patients in managing insulin therapy. PUBLIC HEALTH RELEVANCE: The goal in this grant is to make an intravascular glucose sensor that measures blood glucose levels continuously for 7 days. By maintaining sensor function, this technology will provide health care professionals with immediate changes in patient health and decrease complications. Currently sudden changes in glucose levels are not detected leading to increased health care costs and increased risks to patients.