AGING AND THE PANCREAS

年龄与11型糖尿病发病率增加有关 糖尿病。在研究与年龄有关的下降的特点时， 随着年龄的增长，胰岛素分泌出现异常， 糖尿病患者胰岛素分泌的异常是正常的 衰老过程，再加上对胰岛素释放的需求增加， 设置胰岛素抵抗。最令人感兴趣的是， 这些变化可以逆转。我们治疗年轻人（6个月）和老年人（23 月）Wistar大鼠，输注人重组GLP-1（1.5 pmol/kg体重/分钟），使用ALZET渗透泵 （1003 D）皮下植入颈部48小时。胰岛素mRNA 在GLP-1输注动物中增加3倍。即使是老老鼠， 其胰岛素mRNA的量比年轻人低（低50%）， 大鼠的胰岛素mRNA增加了3倍。胰岛素的异常 通过这种处理，随着衰老的分泌也正常化。大 有趣的是β细胞可以被诱导增殖， 也许新的β细胞可以通过刺激从前体细胞中衍生出来， GLP-1

Aging is associated with an increased incidence of Type 11 diabetes mellitus. On looking at the characteristics of the age-related decline in insulin secretion that occurs with aging, it appears that the abnormality in insulin secretion that occurs in diabetes is an exaggeration of normal aging processes, coupled with increasing demand for insulin release in the setting of insulin resistance. Of great interest is the new information tha these changes can be reversed. We treated young (6 months) and old (23 months) Wistar rats with an infusion of human recombinant GLP-1 (1.5 pmol per kg body weight per minute) using an ALZET osmotic pump (1003D) implanted subcutaneously in the neck for 48 hours. Insulin mRNA was increased 3 fold in the GLP-1 infused animals. Even the old rats, which have a lower amount of mRNA (50% lower) for insulin than young rats, had a 3 fold increase in insulin mRNA. The abnormality in the insulin secretion with aging was also normalized by this treatment. Of great interest is the fact that beta cells can be induced to proliferate and perhaps new beta cells can be derived from precursor cells by stimulation with GLP-1.