Genetic Variation in Amphetamine Response

描述（由申请人提供）：本NRSA F32申请要求为Ajna Hamidovic博士提供两年的博士后支持，以延长她在人类精神药理学研究方面的培训。具体而言，她建议获得培训，以研究急性药物反应的遗传基础，在一个正在进行的NIH资助的研究项目（DA 021336; PI亚伯拉罕帕尔默;共同研究员哈里特德威特）的背景下。这一培训应用程序的广泛目标是为Hamidovic博士提供所需的工具，以启动作为药物滥用研究科学家的独立职业生涯。具体来说，候选人将接受培训，在所有方面进行人类精神药理学研究与遗传变量。她的培训将包括课程，研讨会和one-qnone阅读会议，以提供相关文献的全面知识，以及与此类研究相关的理论和方法问题。她将学习进行研究的各个方面，包括设计，招聘，筛选，测试，助理监督，数据管理和分析，以及准备出版和演示的结果。该研究的具体目的是调查健康志愿者对达非他明（0-20 mg）急性反应的遗传来源，涉及三个领域：i）主观或情绪改变效应，ii）药物对冲动行为的影响，iii）药物对其他认知指标的影响。将对受试者进行与这些指标中的每一项相关的几个基因的多态性基因分型。该培训项目所基于的NIH资助的赠款旨在研究情绪改变的影响，但Hamidovic博士将扩展这项调查，以研究药物对冲动行为和认知措施的影响。 公共卫生相关性：这项研究与公共卫生的相关性是关于对常见滥用药物的主观和行为反应质量的遗传变异性的新信息，这可能有助于研究人员理解为什么有些人容易受到药物成瘾的影响或受到保护。

DESCRIPTION (provided by applicant): This NRSA F32 application requests two years of post doctoral support for Dr. Ajna Hamidovic to extend her training in research in human psychopharmacology. Specifically, she proposes to obtain training to study the genetic basis of responses to acute drugs, in the context of an ongoing NIH-funded research project (DA021336; PI Abraham Palmer; Co Investigator Harriet de Wit). The broad goal of this training application is to provide Dr. Hamidovic with the tools needed to launch an independent career as a research scientist in drug abuse research. Specifically, the candidate will receive training in all aspects of conducting a human psychopharmacological study with genetic variables. Her training will include courses, seminars and one-qnone reading sessions to provide a comprehensive knowledge of the relevant literature, as well as both the theoretical and methodological issues related to this type of research. She will learn all aspects of conducting the research including design, recruitment, screening, testing, supervision of assistants, management and analysis of data, and preparing results for publication and presentations. The specific aims of the research study are to investigate the genetic sources of variation in acute responses to damphetamine (0-20 mg) in healthy volunteers, in three domains: i) subjective or mood altering effects, ii) effects of the drug on impulsive behavior, and iii) effects of the drug on other measures of cognition. Subjects will be genotyped for polymorphisms in several genes that have been associated with each of these measures. The NIH-funded grant upon which this training project is based was designed to investigate the mood-altering effects, but Dr. Hamidovic will extend this investigation to also examine the effects of the drug on impulsive behaviors and measures of cognition. PUBLIC HEALTH RELEVANCE: The relevance of this study to public health is new information about the genetic variability in the quality of magnitide of subjective and behavioral responses to commonly abused drugs which may help researchers understand why some individuals are vulnerable to, or protected from, drug addiction.