Acquisition and Use of Common Ground in Communication

描述（由申请人提供）：本项目的目标是通过研究交流中“共同点”的获取和使用，促进对记忆和语言之间的神经基础和关系的理解。实验方法使用病变方法将神经心理学和神经解剖学的发现联系起来，使用组研究和多例局灶性脑病变神经系统患者的单例研究。拟议的工作建立在我博士工作的一个令人兴奋的发现之上：严重健忘症患者可以在与熟悉的伙伴的定期互动中获得共同点（用于促进快速有效沟通的共享参考标签）。然而，这种学习的关键认知成分和神经解剖学相关性尚未确定。这里的一个主要目的是定义和描述那些支持交流共同点的认知和神经机制。在我的实验工作中使用的任务的性质涉及“现实世界”的学习和交流。事实上，失忆症患者在这种真实世界的协作互动中表现得如此之好，这对于康复的可能性来说是非常令人兴奋的。这项工作的第二个目的是通过设计和实施一组单例干预研究来测试这种模式的临床疗效，该研究使用协作参考任务在有局限性学习和记忆障碍的患者中进行，旨在改善他们的日常功能。

DESCRIPTION (provided by applicant): The goal of this project is to contribute to the understanding of the neural basis for and relationship between memory and language, by investigating the acquisition and use of "common ground" in communication. The experimental approach uses the lesion method to interrelate neuropsychological and neuroanatomical findings, using both group studies and multiple single-case studies of neurological patients with focal brain lesions. The proposed work builds on an exciting finding from my doctoral work: severely amnesic patients can acquire common ground (shared referential labels used to facilitate rapid and efficient communication) in regular interactions with familiar partners. The crucial cognitive components and neuroanatomical correlates of this learning, however, have yet to be determined. One principle aim here is to define and characterize those cognitive and neural mechanisms supporting common ground in communication. The nature of the task used in my experimental work involves "real-world" learning and communication. The fact that individuals with amnesia performed so well in this truly real-world type of collaborative interaction is very exciting with respect to rehabilitation possibilities. The second aim of this work is to test the clinical efficacy of this paradigm by designing and implementing a collection of single case intervention studies using the collaborative referencing task in patients with circumscribed impairments of learning and memory, aimed at improving their daily functioning.